CLDN5 and post-traumatic stress disorder: Consistent with this possibility, DNAm at two CLDN5 loci that were nominally associated with PTSD severity in blood in this study, cg05460329 and cg16773741, were previously found to be associated with worse cognitive performance over time (at the epigenome-wide level of statistical significance) when measured in dlPFC (Hüls et al., 2022).