TTN and tibial muscular dystrophy: For example, heterozygous variants in titin (TTN) were associated with AD Dilated cardiomyopathy 1G (MIM: 604145, which features dysrhythmias and severe congestive heart failure in the first decade of life), and not TTN-associated Familial hypertrophic cardiomyopathy 9 (MIM:613765), Myofibrillar myopathy 9 with early respiratory failure (MIM:603689) or Tardive tibial muscular dystrophy (MIM:600334), which have later onset or are less severe38.