Environmentally influenced metabolites—including diacylglycerols (DG 34:2, DG 32:1), phosphatidylethanolamines (PE 36:4, PE 38:4), and lysophosphatidylcholines (LPC 18:0)—as well as proteins involved in inflammation and vascular biology (ICAM1, ITGB2, MMP12, SERPINA7), were consistently associated with higher T2D risk. Here, SERPINA7 is linked to type 2 diabetes mellitus.