Prior studies have similarly identified IGFBP3 as a biomarker linking the absence of ‘favorable adiposity’ with elevated T2D risk and as a predictive marker for incident cardiovascular events.53 Together, these findings illustrate how environmentally patterned biology (IGFBP2) and genetic ancestry influenced pathways (IGFBP3) converge to shape diabetes risk through distinct but complementary mechanisms. The gene discussed is IGFBP3; the disease is diabetes mellitus.