Given the central role of ATP binding in CFTR functionand dysfunction,accurate identification of ATP binding sites within the protein isparamount for understanding the molecular basis of CF and for developingtargeted therapies., While general ATP binding siteprediction methods have proven useful for a wide range of proteins,they may not be optimally suited for CFTR due to its unique characteristicsas an ion channel within the broader ATP-binding cassette (ABC) transporterfamily. Here, CFTR is linked to cystic fibrosis.