ALB and cancer: As a model substrate, the natural coumarinumbelliprenin (29) was chosen as the drug target, a cytotoxic compoundderived from Ferula species, which is recognized for its cytotoxicactivity against various cancer cell lines. The corresponding prodrug (28), Pro-umbelliprenin, displayed strongbinding affinity to the albumin carrier due to its hydrophobicity,which enhanced the catalytic performance.