PIK3CA and cancer: For instance, changes in the activity of PI3Kαhave been widely associated with multiple types of cancers, particularlysolid tumors, as well as PIK3CA-related overgrowth spectrum (PROS)and activated phosphoinositide 3-kinase delta syndrome (APDS).−, ,  Meanwhile, PI3Kδ and PI3Kγ isoforms are more relatedto immune system pathologies. Nonredundantfunctions associated with PI3Ks are also related to other processesdirectly or indirectly linked to malignancies and can have differentimpacts on specific types of cancers.,