Studies demonstrate that elevated ABCB1 (An et al., 2010; Lu et al., 2019; Qian et al., 2019)and ABCG2 (An et al., 2010; Harris et al., 2014; Wei et al., 2021)expression drives gemcitabine chemoresistance in PC. Here, ABCB1 is linked to pachyonychia congenita.