Moreover, licochalcone A decreased the production of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) through inhibiting the IκB-α degradation in AKI mice (Figure 1; Table 1) (Hu and Liu, 2016). Here, NFKBIA is linked to acute kidney injury.