Mango intake significantly improved patients’ simple clinical colitis activity index (SCCAI) scores, reduced levels of pro-inflammatory cytokines (e.g., interleukin-8 [IL-8], GRO, granulocyte macrophage colony-stimulating factor [GM-CSF]), and beneficially altered the gut microbiota (increased Lactobacillus abundance and butyrate levels) (Kim et al., 2020; Kim et al., 2021). The gene discussed is CSF2; the disease is colitis.