Reports of elevated CPK or myopathy with raltegravir are included in prescribing information (Calza et al., 2014; Cirioni et al., 2013; Lee et al., 2013; Madeddu et al., 2015; Monaghan et al., 2021; Tsai et al., 2016). The gene discussed is PIK3C2A; the disease is myopathy.