Similarly, Ling-Gui-Zhu-Gan (LG) decoction mitigated BA dysregulation in NAFLD mice through coordinated ileal FXR/FGF15 activation and hepatic CYP7A1 suppression (Chen et al., 2024), a finding supported by work on LG oral solution (Wang et al., 2024a). The gene discussed is NR1H4; the disease is metabolic dysfunction-associated steatotic liver disease.