Strikingly, tectorigenin, a methoxylated isoflavone with three hydroxyl groups, upregulated both hepatic and intestinal FXR and CYP7A1 expression, increased the relative abundance of specific Bacteroides species, thereby ameliorating serum BA accumulation and alleviating lipid-related symptoms associated with NAFLD (Duan et al., 2022). The gene discussed is CYP7A1; the disease is metabolic dysfunction-associated steatotic liver disease.