CYP27A1 and metabolic dysfunction-associated steatotic liver disease: PCP extracts ameliorated NAFLD by reshaping the gut microbiota through the reduction of BSH-producing bacteria, which decreased BA deconjugation and increased fecal taurine-conjugated BAs, and by inhibiting ileal FXR/FGF15 while activating hepatic FXR/BSEP/CYP27A1 (Li et al., 2022a).