CYP27A1 and metabolic dysfunction-associated steatotic liver disease: Beyond quercetin derivatives, nobiletin, a polymethoxyflavone from citrus nobiletin, upregulated the expression of CYP7A1 and CYP27A1 and promoted a balanced intestinal microbiota, and reduced lipid levels, alleviating liver fat accumulation and improving NAFLD (Xu et al., 2024).