NR1H4 and metabolic dysfunction-associated steatohepatitis: A complementary mechanism for salidroside was proposed in another study, which found that it ameliorated NASH by upregulating the abundance of Bacteroidota and Bacteroides in the gut microbiota, enhancing fecal BSH activity, reducing hepatic levels of conjugated BAs, such as Tα/β-MCA, and activating FXR and TGR5 (Zhang et al., 2025).