CALCA and migraine disorder: Multiple studies have reported elevated CGRP concentrations in the jugular vein during migraine attacks (Goadsby et al., 1990; Edvinsson and Goadsby, 2019), and higher interictal levels have been detected in the blood, saliva, and tear fluid of migraine patients compared with controls (Cernuda-Morollón et al., 2013; Gallai et al., 1995; Kaiser et al., 2012).