Though direct evidence in stroke models is limited, their ability to modulate TRPM7 suggests promising neuroprotective potential warranting further investigation (Chubanov et al., 2005; Chubanov and Gudermann, 2020; Chubanov et al., 2020; Fisher et al., 2009; Busey et al., 2023). The gene discussed is TRPM7; the disease is stroke disorder.