CNR1 and Euphoria: Cannabis exerts its effects primarily via CB1 and CB2 receptors, with Δ9-tetrahydrocannabinol (THC) producing both therapeutic and adverse psychotropic outcomes, including euphoria, altered perception, and—above certain thresholds—acute impairment of memory, attention, and coordination (Volkow et al., 2014; National Academies of Sciences and Medicine, 2017; Bigand et al., 2019; Arnold, 2021).