NFE2L2 and Myocardial fibrosis: Treatment of H9C2 cells with palmitate significantly increased ROS and redox imbalance, curcumin activated the NRF2 signaling cascade, thereby significantly increasing the expression of downstream genes glutamate-cysteine ligase catalytic (Gclc), HO-1, and NAD(P)H quinone oxidoreductase 1 (NQO-1), and antioxidant response inhibited myocardial fibrosis (Zeng et al., 2015).