In April 2024, the ClinGen Cardiomyopathy Variant Curation Expert Panel (VCEP) adapted the ACMG/AMP criteria for eight of the sarcomeric genes (MYH7, MYBPC3, TNNI3, TNNT2, TPM1, ACTC1, MYL2, and MYL3), providing a refined framework for variant interpretation in these genes. The gene discussed is ACTC1; the disease is cardiomyopathy.