More specifically, in ccRCC, ZDHHC2 has been shown to catalyze palmitoylation of acylglycerol kinase (AGK), promoting its membrane localization and activation of the PI3K/AKT/mTOR axis, which contributes to sunitinib resistance in both cell line and murine models [21]. This evidence concerns the gene MTOR and nonpapillary renal cell carcinoma.