In other types of tumors, KAT6A and KAT6B have been reported to mediate tumor proliferation and malignant progression through the PI3K/AKT signaling pathway, while inhibition of KAT6A and KAT6B results in decreased phosphorylation of PI3K and AKT [59, 64, 129, 228]. This evidence concerns the gene PIK3CA and neoplasm.