CD274 and neoplasm: Although immunosuppressive factors, such as tumor PD‐L1 expression, impair effector T cell cytotoxicity, higher posttreatment densities of intratumoral and peritumoral T cells—including intratumoral PD‐1+ CD8+ subsets—correlate with improved disease‐free survival, highlighting the central prognostic and therapeutic role of T cells [483].