For instance, a pH‐responsive zein–poly(l‐lysine) dendron nanocarrier was developed for the codelivery of siRNA against astrocyte elevated gene‐1 (AEG‐1) and doxorubicin, achieving targeted gene silencing and controlled chemotherapeutic release with minimal cytotoxicity in osteosarcoma models [553]. This evidence concerns the gene MTDH and osteosarcoma.