The protective role of Bregs in RA is primarily attributed to the secretion of IL‐10, a potent T cell suppressor triggered by pathways involving ERK (extracellular signal‐regulated kinase), p38, cyclic adenosine monophosphate (cAMP) response element binding protein, and pSTAT3 (phosphorylated signal transducer and activator of transcription 3) [115]. The gene discussed is IL10; the disease is rheumatoid arthritis.