CEACAM5 and neoplasm: Our study adds to these growing evidence by showing that tumor markers CA 15-3, CEA, and CA 125 correlate with [18F]NaF PET findings, with significantly higher marker levels in PET-positive versus PET-negative groups, a dose–response relationship between marker levels and lesion count (stronger for CA 15–3 and CEA), and confirming CA 15–3 and CEA as independent predictors of PET positivity, while CA 125 showed only a marginal trend.