In summary, this immunoprofile (CD3+, CD5-, CD8-, CD103+, cytotoxic proteins+) is diagnostically pivotal for EATL type I, aligning seamlessly with established diagnostic criteria, particularly in the context of a long-standing, overlooked history of chronic diarrhea that may have represented undiagnosed celiac disease—an important predisposing condition for this aggressive lymphoma. The gene discussed is ITGAE; the disease is lymphoma.