Additionally, KEGG pathway analysis indicated that ELFN1 participates in multiple signaling pathways, including gap junctions, melanoma-related pathways, glioma-related pathways, proteoglycans in cancer, EGF tyrosine kinase inhibitor resistance, Rap1 signaling pathway, B cell receptor signaling pathway, actin cytoskeleton regulation, Ras signaling pathway, prostate cancer-related pathways, choline metabolism in cancer, and melanogenesis pathways (Figure 9F). This evidence concerns the gene EGF and central nervous system cancer.