Among non-thymoma patients (n=14), the frequency of HLA-DQB1 03:03 (25% vs 15.9%, P = 0.195), HLA-C 01:02 (25% vs 15.9%, P = 0.195), HLA-B*52:01 (7.1% vs 3%, P = 0.669) was higher than that in the normal population, the difference was also not statistically significant. The gene discussed is HLA-DQB1; the disease is thymoma.