HIF1A and ovarian carcinoma: Notable examples include reactive oxygen species (ROS)-responsive nanoplatforms co-delivering apatinib and doxorubicin for chemo-photodynamic synergy (192), alginate-optimized niosomes co-encapsulating doxorubicin and cisplatin to overcome ovarian cancer resistance (193) and albumin nanoparticles combining HIF-1α siRNA with methylene blue-mediated photodynamic ablation (194, 195).