Canonical AD inflammatory mediators—including interleukin (IL)-13, IL-19, pulmonary and activation-regulated chemokine (PARC), thymus and activation-regulated chemokine (TARC), chemokine (C-C motif) ligand (CCL)22, CCL26, and CCL27—were upregulated in both clusters, with greater upregulation in the AD_HI cluster. Here, CCL26 is linked to Alzheimer disease.