Known inflammatory mediators of AD inflammation in the “Stepwise” group—CCL17, CCL18, CCL26, CCL22, CCL27, IL-19, and IL-13—are closely connected to the dpy-30 histone methyltransferase complex regulatory subunit (DPY30; MEturquoise) hub, as shown in red in Figure 6B. The gene discussed is PRDM9; the disease is Alzheimer disease.