The OCT GCs thickness of the temporal macular sector reduces later in both ADOA and LHON, while the inferior-internal nasal sector, containing the smallest parvocellular GCs whose axons converge to the PMB, is earlier and more severely affected in both diseases.21,70-72 In chronic and late stages of both diseases, as in our patient cohort, the GC loss extends to all macular areas,.73 In the macula, GCs show higher density and larger caliber in the temporal sector and this could explain the correlation between NfL levels and temporal GCL thickness that we observed in our patients. This evidence concerns the gene NEFL and autosomal dominant optic atrophy.