Based on the analysis of methylome data, we previously found that the methylation level of the promoter region of the lipoic acid synthase (LIAS) gene, a key enzyme responsible for lipoic acid (LA) synthesis, was significantly upregulated in the renal tissue of the DKD rat model, suggesting that it may be involved in the pathophysiological mechanism of DKD. Here, LIAS is linked to diabetic kidney disease.