LIAS and diabetic kidney disease: Thus, we speculated that increased methylation of P3 in the LIAS promoter region reduced LA content by inhibiting LIAS expression and weakening the ability to resist oxidative stress, thereby promoting the occurrence of DKD; whereas increased methylation of E1 in the LIAS exon region may increase LA content by upregulating LIAS expression and resisting oxidative stress, thereby playing a protective role in the occurrence of DKD.