Under physiological concentrations, HO-1 exerts antioxidant effects to protect neurons from ROS attack, potentially through mechanisms involving antioxidant promotion via metabolites [73, 74], reduction of tau expression and β-amyloid toxicity in neuroblastoma cells, and enhancement of neurotrophic factor production via the Nrf2/HO-1/BVR-A pathway [58–60]. This evidence concerns the gene HMOX1 and neuroblastoma.