AKT1 and cancer: In addition, SalB regulates AKT/mTOR (55), Hippo/YAP (56), PI3K/AKT/HIF-1α (57), TGF-β1/Smad (58), mortalin/RECK/STAT3 (59), and NDRG2/PTEN/PI3K/AKT (60) signaling pathways to promote anti-cancer effects (Figure 1C) and exerts neuroprotective effects by modulating CD40/NF-κB (61), IGF-1/AKT (62), ERK/CREB/BDNF (63), and miRNA-1/MLCK (64) signaling pathways (Figure 1D).