Among the potential ADC targets in ovarian cancer, the immune checkpoint molecules B7-H3 (also known as CD276) and B7-H4 (also referred to as VTCN1, B7x, or B7S1) have emerged as particularly promising due to their overexpression in ovarian tumors and their role in immune evasion (26–28). This evidence concerns the gene VTCN1 and ovarian carcinoma.