Although the specific role of this kinase in regulating MC function in allergy and neuroinflammation remains to be elucidated, we propose that activation of this kinase, through phosphorylation of Rab12 and Rab7, enables external triggers to coordinate the transport of lysosome-related SGs with that of degradative lysosomes, thereby coupling SG secretion with receptor downregulation. The gene discussed is RAB12; the disease is allergic disease.