NLRP3 and IgA glomerulonephritis: Further mechanistic insights reveal that colorectal neoplasia differentially expressed (CRNDE), a long non-coding RNA, exacerbates IgA nephropathy by promoting NLRP3 inflammasome activation in macrophages; conversely, CRNDE suppression enhances NLRP3 degradation, thereby attenuating renal inflammation (155).