NLRP3 and systemic lupus erythematosus: In SLE, immune complexes containing anti-DNA or anti-RNA autoantibodies activate the NLRP3 inflammasome in monocytes and macrophages via two synergistic mechanisms: (i) upregulation of TLR-dependent NF-κB signaling, which primes inflammasome component expression, and (ii) induction of mtROS, which provides the critical second signal for NLRP3 assembly.