observed significant insulin resistance and glucose intolerance in an obese animal model, accompanied by renal inflammation and increased expression of IL-1β, IL-18, TNF-α, and IL-6, potentially mediated by NF-κB/NLRP3 signaling, which was further validated in human immortalized renal tubular epithelial cells (129). This evidence concerns the gene NFKB1 and Insulin resistance.