A growing body of evidence indicates that the NLRP3 inflammasome plays a pivotal role in both the initiation and progression of IgA nephropathy and is intimately linked to injury of intrinsic renal cells—including podocytes, mesangial cells, glomerular endothelial cells, and tubular epithelial cells (155–157). Here, NLRP3 is linked to IgA glomerulonephritis.