ZIC4 and multiple sclerosis: Two patients (both harbouring baseline IC-Abs) had a history of autoimmune diseases (one patient with baseline anti-Hu antibodies had a history of systemic erythematous lupus with cutaneous and articular involvement; one patient with anti-SOX1 and anti-Zic4 antibodies had multiple sclerosis in clinical remission and without specific immune-active treatment at the time of study enrolment).