For instance, 5′tiRNA-Pro-TGG may facilitate the progression of serrated pathway colorectal cancer (CRC) by modulating metabolic and immune pathways through its interaction with HPSE2 and regulation of HPSE2 expression in sessile serrated lesions (SSLs) and BRAF-mutant CRC (7, 8). Here, HPSE2 is linked to colorectal carcinoma.