CD274 and neoplasm: Tumor characteristics played a critical role, with PD-L1 CPS >20 tumors nearly tripling the likelihood of pCR (OR = 2.95, p < 0.001), whereas poorly differentiated histology (OR = 0.32, p < 0.001) and Stage IV disease (OR = 0.48, p = 0.002) were associated with poorer responses.