Moreover, increased UCK2 levels in HCC have been shown to promote tumor growth and metastasis by activating critical oncogenic signaling pathways, including STAT3, Wnt/β-catenin, and EGFR-AKT (49–51), whereas UCK2 knockdown significantly suppresses tumor cell proliferation (52). The gene discussed is AKT1; the disease is hepatocellular carcinoma.