Notably, in hepatocellular carcinoma models, primary bile acids can upregulate C-X-C motif chemokine ligand 16 (CXCL16) expression on liver sinusoidal endothelial cells (LSECs), thereby recruiting and activating Natural Killer T (NKT) cells to enhance antitumor immunity. The gene discussed is CXCL16; the disease is hepatocellular carcinoma.