In glioma, perivascular SPP1–CD44 signaling and mesenchymal programs, and the purinergic CD39–CD73 interface between microglia and tumor cells, are recurrently enriched in defined niches; spatial frameworks that quantify these arrangements have been associated with prognostic and biological stratification and therefore constitute suitable benchmarks for LR pipelines. This evidence concerns the gene SPP1 and central nervous system cancer.