By integrating the signature genes associated with YDC and ccRCC, we identified nine overlapping candidate genes: MXD3, DEF6, IFNG, TBC1D10C, CCDC88B, ITGAD, PLEKHN1, PLCB2, and FUT7 (Figure 4A). The gene discussed is DEF6; the disease is nonpapillary renal cell carcinoma.