By integrating the signature genes associated with YDC and ccRCC, we identified nine overlapping candidate genes: MXD3, DEF6, IFNG, TBC1D10C, CCDC88B, ITGAD, PLEKHN1, PLCB2, and FUT7 (Figure 4A). Here, PLEKHN1 is linked to nonpapillary renal cell carcinoma.