MC4R and type 2 diabetes mellitus: Beyond TCF7L2, the Progress in Diabetes Genetics in Youth (ProDiGY) study—analyzing data from diverse cohorts in the TODAY, SEARCH, and T2D-GENES studies—identified six genome-wide significant loci associated with T2DM: MC4R, CDC123, KCNQ1, IGF2BP2, and SLC16A11, located near or within PHF2 (37).