It is interesting to underline that some of the clinical and laboratory features that we described for the “hyperinflammatory” flares, have been associated, according to recent literature data, with a high interferon (IFN) signature, particularly fever, lymphopenia, hypocomplementemia, multiple autoantibodies positivity and resistance to glucocorticoids (28–30). The gene discussed is IFNA1; the disease is Fever.