A total of 444 differentially expressed genes in AF were identified, and 9 AF-related mitophagy ion channel genes (AFRMICGs) were obtained (BAX, CTNNB1, DPYSL2, EPHX1, GLUL, GNB2, MIF, MYC, TLR4). The gene discussed is DPYSL2; the disease is atrial fibrillation.