The significantly enriched signaling pathways included various diseases (Rheumatoid arthritis, Lipid and atherosclerosis), immune responses (antigen processing and presentation, Th17 cell differentiation, natural killer cell mediated cytotoxicity, B cell receptor and T cell receptor signaling pathway), inflammatory responses (leukocyte transendothelial migration), NF-kappa B, JAK-STAT, and mTOR signaling pathway (Figures 2H,I). Here, MTOR is linked to rheumatoid arthritis.