LMNA and mandibuloacral dysplasia with type A lipodystrophy: This finding represents the first association, to our knowledge, between the homozygous LMNA c.785A > G (p.Glu262Gly) mutation and significant severe early-onset cardiac valvular calcification manifesting as a prominent feature within the MADA phenotype, thus expanding the clinical spectrum associated with MADA and this specific LMNA variant.