LMNA and Hutchinson-Gilford progeria syndrome: These disorders range from muscular dystrophies (e.g., Emery-Dreifuss muscular dystrophy), peripheral neuropathy (Charcot-Marie-Tooth disease type 2B1), lipodystrophy syndromes (e.g., Dunnigan-type familial partial lipodystrophy), and severe progeroid syndromes like Hutchinson-Gilford progeria syndrome (HGPS) and MADA itself (7).