The two genes demonstrated good diagnostic efficacy in the hyperthyroidism validation set GSE276271 (AUC: TMEM127, 0.636; CXCL16, 0.591) and in the AF validation set GSE2240 (AUC: TMEM127, 0.745; CXCL16, 0.720). Here, TMEM127 is linked to atrial fibrillation.