ERBB2 and cancer: Black non-Hispanic patients aged 75 and older diagnosed with distant stage, grade IV cancer, with the primary site unspecified, only one-sided unspecific laterality, and an HR-/HER2-negative subtype, who received chemotherapy but did not have surgery as systemic therapy, tested negative for progesterone, and had a household income of less than $50,000.00 are among the worst prognostic factors identified in our database.