Major diagnostic criteria include polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor (VEGF), and Castleman disease, while minor criteria encompass organomegaly, endocrinopathy, characteristic skin changes, papilloedema, extravascular fluid overload, and thrombocytosis [1]. Here, VEGFA is linked to endocrine system disorder.