Histologically, the tumor has malignant features such as atypical cells, nuclear hyperchromasia, increased mitotic figures, angiogenesis, and necrotic regions. We present a 49-year-old male with a history of a left frontotemporal glioblastoma isocitrate dehydrogenase (IDH) wild type and O6-methylguanine-DNA methyltransferase (MGMT) unmethylated (~ 95% of gross total). The gene discussed is IDH3A; the disease is neoplasm.