Unlike metabolic and genetic neuropathies, autoimmune forms such as chronic inflammatory demyelinating polyneuropathy, Guillain-Barré syndrome (GBS), and the recently defined autoimmune neuropathy are associated with immune attacks on nerve components, particularly nodal and paranodal proteins such as neurofascin-155, neurofascin-186, contactin-1, and CASPR-1 [1]. The gene discussed is CNTNAP1; the disease is Guillain-Barre syndrome.