The univariate analysis revealed that the risk of CRBSI was significantly associated with hypertension (OR 3.941, 95% CI 2.050–7.577), PN energy proportion relative to REE > 0.6 (PN/REE > 0.6) (OR 4.238, 95% CI 2.405–7.469), daily PN volume > 1650 mL (OR 1.988, 95% CI 1.150–3.434), non-protein calorie-to-nitrogen (C/N) ratio ≥ 100 kcal/g N (OR 2.231, 95% CI 1.241–4.011), glucose-to-lipid ratio ≤ 1 (OR 1.789, 95% CI 1.037–3.087), lymphocyte count (LYC) < 1 × 109/L (OR 6.325, 95% CI 3.493–11.453), and prealbumin ≤ 200 mg/L (OR 3.109, 95% CI 1.728–5.593). Here, TTR is linked to hypertensive disorder.