CUR and EGCG have also been shown to activate Nrf2 in rotenone- or 6-OHDA-induced PD models, via direct Keap1 modification or p62-mediated Keap1 autophagic degradation, respectively—resulting in elevated antioxidant enzyme levels and significantly reduced oxidative damage in model animals (47, 52). This evidence concerns the gene KEAP1 and Parkinson disease.