Xu et al. (48) reported that daily administration of 50 mg/kg curcumin (intraperitoneal) effectively prevented PD-like symptoms induced by rotenone in mice, likely due to its inhibition of microglial NF-κB-NLRP3 inflammasome activation and reduction of pro-inflammatory cytokines such as IL-1β and IL-18. The gene discussed is IL1B; the disease is Parkinson disease.